Recurrent parasitemias and population dynamics of Plasmodium vivax polymorphisms in rural Amazonia.

@article{OrjuelaSnchez2009RecurrentPA,
  title={Recurrent parasitemias and population dynamics of Plasmodium vivax polymorphisms in rural Amazonia.},
  author={Pamela Orjuela-S{\'a}nchez and Natal Santos da Silva and M{\^o}nica da Silva-Nunes and Marcelo U Ferreira},
  journal={The American journal of tropical medicine and hygiene},
  year={2009},
  volume={81 6},
  pages={961-8}
}
Clinical trials documented alarming post-treatment Plasmodium vivax recurrence rates caused by recrudescence of surviving asexual blood stages, relapse from hypnozoites, or new infections. Here we describe high rates of P. vivax recurrence (26-40% 180 days after treatment) in two cohorts of rural Amazonians exposed to low levels of malaria transmission after a vivax malaria episode treated with chloroquine-primaquine. Microsatellite analysis of 28 paired acute infection and recurrence parasites… CONTINUE READING

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