Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosis.

@article{Friboulet2008RecurrentOO,
  title={Recurrent overexpression of c-IAP2 in EBV-associated nasopharyngeal carcinomas: critical role in resistance to Toll-like receptor 3-mediated apoptosis.},
  author={Luc Friboulet and Catherine Pioche-Durieu and Sandrine Rodriguez and Alexander Valent and Sylvie Souquere and Hugues Ripoche and Abdelmajid Khabir and Sai Wah Tsao and Jacques Bosq and Kwok Wai Lo and Pierre Busson},
  journal={Neoplasia},
  year={2008},
  volume={10 11},
  pages={
          1183-94
        }
}
The oncogenic process leading to nasopharyngeal carcinoma (NPC) requires the combination of genetic and epigenetic alterations, latent infection by the Epstein-Barr virus and local inflammation. A transcriptome analysis of NPC xenografts identified the gene encoding the cellular inhibitor of apoptosis protein 2 (c-IAP2) among the top five most intensely expressed. Consistently, the very high levels of the c-IAP2 protein were detected in 11 of 13 NPC biopsies. RMT 5265, a structural analog of… CONTINUE READING
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