Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.

  title={Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors.},
  author={Constance A. Griffin and Anita L. Hawkins and Colleen Dvorak and Carol T Henkle and Tom Ellingham and Elizabeth J Perlman},
  journal={Cancer research},
  volume={59 12},
Inflammatory myofibroblastic tumor (IMT) is a relatively rare soft tissue tumor. The reactive versus neoplastic pathogenesis of this tumor is unresolved. We found clonal chromosome aberrations involving 2p23 upon metaphase analysis of two IMTs. Fluorescence in situ hybridization with a probe flanking the ALK gene at 2p23 demonstrated rearrangement of the probe in both of these cases and in a third case, and immunohistochemistry revealed ALK expression in all three cases. 2p22-24 involvement has… CONTINUE READING


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ISCN: An International System for Human Cytogenetic Nomenclature

  • Mitelman, F. ed
  • Basel, Switzerland: S. Karger,
  • 1995
Highly Influential
6 Excerpts

Analysis of the (2;5)(p23;q35) translocation in CD30 1 primary cutaneous lymphoproliferative disorders and Hodgkin’s disease

  • G Wood
  • Leuk. Lymphoma,
  • 1998
2 Excerpts

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