Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl.

@article{Moss2006RecurrentHI,
  title={Recurrent hypoxia in rats during development increases subsequent respiratory sensitivity to fentanyl.},
  author={Immanuela Rav{\'e} Moss and Karen A. Brown and A. Laferriere},
  journal={Anesthesiology},
  year={2006},
  volume={105 4},
  pages={715-8}
}
BACKGROUND In children with a history of significant obstructive sleep apnea who undergo adenotonsillectomy, postsurgical administration of opiates has been alleged to be associated with an increased risk for respiratory complications, including respiratory depression. The authors hypothesize that this association is due to an effect of recurrent hypoxemia that accompanies more severe obstructive sleep apnea on altered responsiveness to subsequent exogenous opiates. METHODS The current study… CONTINUE READING
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