Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats.

@article{Osundiji2011RecurrentHI,
  title={Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats.},
  author={Mayowa A. Osundiji and Paul Hurst and Stephen P. Moore and S. Pauliina Markkula and Chen Yu Yueh and Ashwini Swamy and Shu Hoashi and Jill S Shaw and Christine H Riches and Lora K Heisler and Mark Evans},
  journal={Metabolism: clinical and experimental},
  year={2011},
  volume={60 4},
  pages={550-6}
}
The mechanisms underpinning impaired defensive counterregulatory responses to hypoglycemia that develop in some people with diabetes who suffer recurrent episodes of hypoglycemia are unknown. Previous work examining whether this is a consequence of increased glucose delivery to the hypothalamus, postulated to be the major hypoglycemia-sensing region, has been inconclusive. Here, we hypothesized instead that increased hypothalamic glucose phosphorylation, the first committed intracellular step… CONTINUE READING

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