Recurrent herpes simplex virus type 1 infection precipitated by the impaired production of interleukin-2, alpha-interferon, and cell-mediated cytotoxicity.

@article{Kuo1990RecurrentHS,
  title={Recurrent herpes simplex virus type 1 infection precipitated by the impaired production of interleukin-2, alpha-interferon, and cell-mediated cytotoxicity.},
  author={Y C Kuo and C Y Lin},
  journal={Journal of medical virology},
  year={1990},
  volume={31 3},
  pages={183-9}
}
In order to understand whether immunosuppression due to the primary host defense defect provokes the reactivation of herpes simplex virus type 1 (HSV-1), 11 healthy persons were evaluated immunologically after recurrence of herpes. A decrease was found in the production of interleukin-2 (IL-2) and alpha-interferon (IFN-alpha) to HSV-1 antigen stimulation in the recrudescent stage (0 to 3 days after onset of the lesion). The cell-mediated cytotoxicity also decreased. To clarify the relationship… CONTINUE READING

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