Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma.

@article{Pasic2010RecurrentFC,
  title={Recurrent focal copy-number changes and loss of heterozygosity implicate two noncoding RNAs and one tumor suppressor gene at chromosome 3q13.31 in osteosarcoma.},
  author={Ivan Pasic and Adam Shlien and Adam David Durbin and Dimitrios J Stavropoulos and Berivan Baskin and Peter N. Ray and Ana Kundid Novokmet and David Malkin},
  journal={Cancer research},
  year={2010},
  volume={70 1},
  pages={160-71}
}
Osteosarcomas are copy number alteration (CNA)-rich malignant bone tumors. Using microarrays, fluorescence in situ hybridization, and quantitative PCR, we characterize a focal region of chr3q13.31 (osteo3q13.31) harboring CNAs in 80% of osteosarcomas. As such, osteo3q13.31 is the most altered region in osteosarcoma and contests the view that CNAs in osteosarcoma are nonrecurrent. Most (67%) osteo3q13.31 CNAs are deletions, with 75% of these monoallelic and frequently accompanied by loss of… CONTINUE READING