Recurrent biparental hydatidiform mole: additional evidence for a 1.1-Mb locus in 19q13.4 and candidate gene analysis.

@article{Panichkul2005RecurrentBH,
  title={Recurrent biparental hydatidiform mole: additional evidence for a 1.1-Mb locus in 19q13.4 and candidate gene analysis.},
  author={Prisana C Panichkul and Tarek Khalaf Al-Hussaini and Rebecca Sierra and Catherine D. Kashork and Edwina J. Popek and David Stockton and Ignatia B. van den Veyver},
  journal={Journal of the Society for Gynecologic Investigation},
  year={2005},
  volume={12 5},
  pages={376-83}
}
OBJECTIVES A maternal autosomal recessive mutation causing recurrent biparentally inherited complete hydatidiform moles (BiCHM) in affected women was previously mapped to a 12.4-cM interval in 19q13.4, which was recently further narrowed to a smaller 1.1-Mb region at the centromeric end. It is believed that the mutant gene in this condition is a major contributor to the regulation of imprinting in the maternal germline. To confirm and possibly narrow the critical interval we studied additional… CONTINUE READING

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