Recurrent and functional regulatory mutations in breast cancer

@article{Rheinbay2017RecurrentAF,
  title={Recurrent and functional regulatory mutations in breast cancer},
  author={Esther Rheinbay and Prasanna Parasuraman and Jonna Grimsby and Grace Tiao and Jesse M. Engreitz and Jaegil Kim and Michael S. Lawrence and Amaro Taylor-Weiner and Sergio Arturo Rodr{\'i}guez-Cuevas and Mara Rosenberg and Julian Hess and Chip Stewart and Yosef E. Maruvka and Petar Stojanov and Mar{\'i}a M. Lorido Cort{\'e}s and Sara Seepo and Carrie L. Cibulskis and Adam Tracy and Trevor J. Pugh and Jesse Lee and Zongli Zheng and Leif William Ellisen and Anthony John Iafrate and Jesse S Boehm and Stacey Bolk Gabriel and Matthew L Meyerson and Todd R. Golub and Jos{\'e} Baselga and Alfredo Hidalgo-Miranda and Toshi Shioda and Andre Bernards and Eric S. Lander and Gad Getz},
  journal={Nature},
  year={2017},
  volume={547},
  pages={55-60}
}
Genomic analysis of tumours has led to the identification of hundreds of cancer genes on the basis of the presence of mutations in protein-coding regions. By contrast, much less is known about cancer-causing mutations in non-coding regions. Here we perform deep sequencing in 360 primary breast cancers and develop computational methods to identify significantly mutated promoters. Clear signals are found in the promoters of three genes. FOXA1, a known driver of hormone-receptor positive breast… CONTINUE READING
BETA

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 38 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Comprehensive assessment of cancer missense mutation clustering in protein structures

  • A Kamburov
  • Proc Natl Acad Sci USA
  • 2015

Similar Papers

Loading similar papers…