Recurrent TRIO Fusion in Nontranslocation–Related Sarcomas

@article{Delespaul2016RecurrentTF,
  title={Recurrent TRIO Fusion in Nontranslocation–Related Sarcomas},
  author={Lucile Delespaul and Tom Lesluyes and Ga{\"e}lle P{\'e}rot and C{\'e}line Brulard and Lydia Lartigue and Jessica Baud and Pauline Lagarde and Sophie Le Guellec and Agn{\`e}s Neuville and Philippe Terrier and Dominique Vince-Ranch{\`e}re and Susanne Schmidt and Anne Debant and Jean-Michel Coindre and Fr{\'e}d{\'e}ric Chibon},
  journal={Clinical Cancer Research},
  year={2016},
  volume={23},
  pages={857 - 867}
}
Purpose: Despite various differences, nontranslocation-related sarcomas (e.g., comprising undifferentiated pleomorphic sarcoma, leiomyosarcoma, myxofibrosarcoma) are unified by their complex genetics. Extensive analysis of the tumor genome using molecular cytogenetic approaches showed many chromosomal gains, losses, and translocations per cell. Genomic quantitative alterations and expression variations have been extensively studied by adapted high-throughput approaches, yet translocations still… 

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