Recurrent Respiratory Papillomatosis: A Review

  title={Recurrent Respiratory Papillomatosis: A Review},
  author={Craig S Derkay and Brian J. Wiatrak},
  journal={The Laryngoscope},
Recurrent respiratory papillomatosis (RRP), which is caused by human papillomavirus types 6 and 11, is the most common benign neoplasm of the larynx among children and the second most frequent cause of childhood hoarseness. After changes in voice, stridor is the second most common symptom, first inspiratory and then biphasic. Less common presenting symptoms include chronic cough, recurrent pneumonia, failure to thrive, dyspnea, dysphagia, or acute respiratory distress, especially in infants… 
Recurrent Respiratory Papillomatosis
The clinical course including patient’s history, physical examination, airway endoscopy, surgical and nonsurgical treatment modalities are discussed, and there is insufficient evidence to support effectiveness of adjuvant medical treatment in the management of RRP.
Recurrent respiratory papillomas (RRP) are rare benign, indolent aerodigestive tract tumors, commonly found in the larynx and caused primarily by human papilloma viruses (HPV) types 6 and 11. Though
Recurrent Respiratory Papillomatosis: an extensive review
Recurrent respiratory papillomatosis (RRP) is characterized by the recurrence of benign tumors (papillomata) in the aero digestive tract caused by Human Papilloma Virus. The burden for the patient
Recurrent Respiratory Papillomatosis and Human Papillomavirus
This chapter reviews the etiology, diagnosis, therapeutic options, and prevention of RRP, which is mainly associated with low-risk human papillomavirus types 6 and 11.
Recurrent Respiratory Papillomatosis Successfully Treated with Gefitinib: A Case Study
Tyrosine kinase inhibitors of epidermal growth factor receptor represent a new treatment possibility for a long-term benefit for patients with recurrent respiratory papillomatosis in whom other treatment modalities had failed.
Juvenile-onset recurrent respiratory papillomatosis with pulmonary involvement and carcinomatous transformation
The case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation, is reported, revealing the presence of HPV type 11, which is associated with rapid and aggressive progression.
Malignant Transformation and Distal Airway Complications
Treatment strategies for benign papilloma continue to hinge on surgical removal, with considerations for adjuvant therapy when airway obstruction is imminent, frequency of surgery is intolerable, or distal spread is diagnosed.
It is considered that both adaptive and innate immune response made by patients with papillomatosis support chronic infection, and patients with laryngeal papillomas are unable to produce an effective HPVspecific T-cell response.


Extraesophageal acid reflux and recurrent respiratory papilloma in children.
Tracheobronchial Extension of Recurrent Respiratory Papillomatosis
As this study shows, tracheobronchial involvement continues to complicate surgical treatment in this challenging disease process.
A Staging System for Assessing Severity of Disease and Response to Therapy in Recurrent Respiratory Papillomatosis
Recurrent respiratory papillomatosis is an orphan disease with an incidence in the United States estimated at between 1500 and 2500 new cases per year, and is considered the most common benign neoplasm of the larynx.
Clinical course of recurrent respiratory papillomatosis in Danish children.
The clinical course of RP is characterized by a high frequency of surgeries soon after diagnosis that diminishes over time and with increasing age, and the trend for children with recurrent disease was a decreasing rate of surgical procedures.
Gefitinib therapy for life-threatening laryngeal papillomatosis.
A EGFR tyrosine kinase inhibitor is tried in a patient with end-stage disease in whom other therapies had failed, and viral persistence occurs after treatment with these adjuvant modalities, further contributing to the challenge of treating patients who have this potentially devastating disease.
Pulmonary manifestations of juvenile laryngotracheal papillomatosis.
In seven cases, the lung lesions proved to be benign squamous cell proliferations or papillomas, with central cavities containing debris or air, which suggests that fragments become detached during endoscopic resection, and are carried down the airways by airflow.
Pediatric Respiratory Papillomatosis: Prognostic Role of Viral Typing and Cofactors
The early airway obstructive course associated with HPV‐11, however, had no bearing on achieving eventual disease remission, with decannulation achieved in eight of nine children.
National registry for juvenile-onset recurrent respiratory papillomatosis.
The registry has established the clinical course of JORRP in a large sample representative of the United States and young age was the most important determinant of disease severity (frequency of surgery, extent of disease at diagnosis, and progression of disease).
Treatment of recurrent respiratory papillomatosis with human leukocyte interferon. Results of a multicenter randomized clinical trial.
The data do not show that interferon is either curative or of substantial value as an adjunctive agent in the long-term management of recurrent respiratory papillomatosis.
Case of Progressive Dysplasia Concomitant with Intralesional Cidofovir Administration for Recurrent Respiratory Papillomatosis
A 28-year-old woman with recurrent respiratory papillomatosis who was treated with intralesional cidofovir at the time of surgery over the span of 27 months demonstrated benign disease with progression to severe dysplasia during the treatment time.