Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 is Associated with an Increased HLA-C2 Allelic Frequency.

@article{Dambaeva2016RecurrentPL,
  title={Recurrent Pregnancy Loss in Women with Killer Cell Immunoglobulin-Like Receptor KIR2DS1 is Associated with an Increased HLA-C2 Allelic Frequency.},
  author={Svetlana V. Dambaeva and Dong Hyung Lee and Nayoung Sung and Chi-Yao Chen and Shihua Bao and Alice Gilman-Sachs and Joanne Y H Kwak-Kim and Kenneth D Beaman},
  journal={American journal of reproductive immunology},
  year={2016},
  volume={75 2},
  pages={
          94-103
        }
}
PROBLEM During human pregnancy, the uterine lining is highly populated with killer-immunoglobulin-like receptor (KIR)-expressing NK cells that recognize HLA-C molecules on trophoblast cells. The goal of this study was to analyze the KIR gene contents and frequencies in a N. American cohort of women with RPL of unknown etiology to evaluate whether there is a genetic susceptibility to RPL based on a woman's KIR repertoire and her HLA-C group, as well as the HLA-C group of the partner. METHOD OF… CONTINUE READING
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