Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia

@article{Bellanger2014RecurrentJA,
  title={Recurrent JAK1 and JAK3 somatic mutations in T-cell prolymphocytic leukemia},
  author={Dorine Bellanger and Virginie Jacquemin and Martine Chopin and Ga{\"e}lle Pierron and Olivier Adrien Bernard and Jacques Ghysdael and Marc-Henri Stern},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={417-419}
}
T-cell prolymphocytic leukemia (T-PLL) is a rare hematological disease in elderly people characterized by a mature T-cell phenotype, a large tumor burden and a dismal prognosis (for review see). Highly recurrent genetic alterations have been identified, including chromosomal rearrangements between TCR genes and MTCP1/TCL1 paralogs, ATM inactivation and haploinsufficiency of the CDKN1B gene in about 50% of the cases. However, T-PLL genome profiling revealed large number of recurrent gains and… CONTINUE READING

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