Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).

@article{Freier2007RecurrentFA,
  title={Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).},
  author={Kolja Freier and Carsten Schwaenen and Carsten Sticht and Christa Flechtenmacher and Joachim M{\"u}hling and Christof Hofele and Bernhard Radlwimmer and Peter Lichter and Stefan Joos},
  journal={Oral oncology},
  year={2007},
  volume={43 1},
  pages={60-6}
}
Chromosomal aberrations are known to have an impact on the initiation and progression of oral squamous cell carcinoma (OSCC), but individual genes involved in OSCC pathogenesis are poorly described. To elucidate the molecular events underlying oral carcinogenesis, a set of primary OSCC were screened for distinct genetic imbalances by means of array-based comparative genomic hybridisation. For this, a DNA array was used containing 812 genomic targets including oncogenes, tumour-suppressor genes… CONTINUE READING