Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice

@inproceedings{Lew2013RecurrentET,
  title={Recurrent Exposure to Subclinical Lipopolysaccharide Increases Mortality and Induces Cardiac Fibrosis in Mice},
  author={Wilbur Y. W. Lew and Evelyn Bayna and Erminia Dalle Molle and Nancy D. Dalton and Ngai Chin Lai and Valmik Bhargava and Vincent L. Mendiola and Paul C Clopton and Tong Yu Tang},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Circulating subclinical lipopolysaccharide (LPS) occurs in health and disease. Ingesting high fatty meals increases LPS that cause metabolic endotoxemia. Subclinical LPS in periodontal disease may impair endothelial function. The heart may be targeted as cardiac cells express TLR4, the LPS receptor. It was hypothesized that recurrent exposure to subclinical LPS increases mortality and causes cardiac fibrosis. METHODS C57Bl/6 mice were injected with intraperitoneal saline (control… CONTINUE READING
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