Recurrent CDKN1B (p27) mutations in hairy cell leukemia.

  title={Recurrent CDKN1B (p27) mutations in hairy cell leukemia.},
  author={Sascha Dietrich and Jennifer Huellein and Stanley Chun-Wei Lee and Barbara Hutter and David Gonz{\'a}lez and Sandrine Jayne and Martin J S Dyer and M Oleś and Monica Else and Xiyang Liu and Mikołaj Słabicki and Bian Wu and Xavier Troussard and Jan D{\"u}rig and Mindaugas Andrulis and Claire E. Dearden and Christof von Kalle and Martin Granzow and Anna Jauch and Stefan Fr{\"o}hling and Wolfgang Huber and Manja Meggendorfer and Torsten Haferlach and Anthony D. Ho and Daniela Richter and Benedikt Brors and Hanno Glimm and Estella Matutes and Omar Abdel Wahab and Thorsten Zenz},
  volume={126 8},
Hairy cell leukemia (HCL) is marked by near 100% mutational frequency of BRAFV600E mutations. Recurrent cooperating genetic events that may contribute to HCL pathogenesis or affect the clinical course of HCL are currently not described. Therefore, we performed whole exome sequencing to explore the mutational landscape of purine analog refractory HCL. In addition to the disease-defining BRAFV600E mutations, we identified mutations in EZH2, ARID1A, and recurrent inactivating mutations of the cell… CONTINUE READING
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