Corpus ID: 33683664

Recurrent BCAM-AKT 2 fusion gene leads to a constitutively activated AKT 2 fusion kinase in high-grade serous ovarian carcinoma

@inproceedings{Kannana2015RecurrentB2,
  title={Recurrent BCAM-AKT 2 fusion gene leads to a constitutively activated AKT 2 fusion kinase in high-grade serous ovarian carcinoma},
  author={Kalpana Kannana and Cristian Coarfab and Pei-Wen Chaoa and Liming Luoa and Yan Wanga and Amy E. Brinegara and Shannon M. Hawkinsc and Aleksandar Milosavljevicc and Martin M. Matzuka and L. Yena},
  year={2015}
}
  • Kalpana Kannana, Cristian Coarfab, +7 authors L. Yena
  • Published 2015
  • High-grade serous ovarian cancer (HGSC) is among the most lethal forms of cancer in women. Excessive genomic rearrangements, which are expected to create fusion oncogenes, are the hallmark of this cancer. Here we report a cancer-specific gene fusion between BCAM, a membrane adhesion molecule, and AKT2, a key kinase in the PI3K signaling pathway. This fusion is present in 7% of the 60 patient cancers tested, a significant frequency considering the highly heterogeneous nature of this malignancy… CONTINUE READING

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