Recurrence of primary sclerosing cholangitis following liver transplantation

@article{Graziadei1999RecurrenceOP,
  title={Recurrence of primary sclerosing cholangitis following liver transplantation},
  author={Ivo W. Graziadei and Russell H. Wiesner and Kenneth P Batts and Paul J. Marotta and Nicholas F. LaRusso and Michael K. Porayko and J. Eileen Hay and Gregory J. Gores and Michael R. Charlton and Jurgen Ludwig and John J. Poterucha and Jeffery L. Steers and Ruud A. F. Krom},
  journal={Hepatology},
  year={1999},
  volume={29}
}
Recurrence of primary sclerosing cholangitis (PSC) following liver transplantation has been suggested; however, it has not been fully defined because of numerous complicating factors and the lack of diagnostic criteria. In the present study, we investigated the recurrence of PSC by developing strict criteria and applying them to a large cohort of PSC patients who underwent liver transplantation. Between March 1985 and June 1996, 150 PSC patients underwent liver transplantation at the Mayo… Expand
Can we avoid primary sclerosing cholangitis recurrence?
  • C. Levy
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2016
TLDR
This study could not firmly demonstrate that active colitis after transplant was independently associated with increased rates of PSC recurrence, but confirmed the presence of inflammatory bowel disease (IBD), older donor age, and higher international normalized ratio (INR) at the time of liver transplant. Expand
Features of Recurrent Primary Sclerosing Cholangitis in Two Consecutive Liver Allografts After Liver Transplantation
TLDR
The recurrence of the disease in two allografts in an immunosuppressed patient, in the absence of ischemia, chronic rejection, or any known pathogen, raises the question of the role of an unidentified infectious agent in the etiopathogenesis of PSC. Expand
Recurrence of primary sclerosing cholangitis after liver transplantation
  • I. Graziadei
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2002
TLDR
In conclusion, several studies provided convincing evidence that PSC recurs after OLT, with an incidence of 5% to 20% and an interval to diagnosis of at least 1 year after OLM, and recurrent disease did not influence patient or graft survival after a mean follow‐up of 4.5 years. Expand
Risk factors for recurrence of primary sclerosing cholangitis after liver transplantation
TLDR
A history of ACR and presence of HLA‐DRB1*08 are associated with increased risk of recurrent PSC, suggesting an immunologic mechanism for this syndrome. Expand
Different immunosuppressive regimens and recurrence of primary sclerosing cholangitis after liver transplantation
  • M. Kugelmas, Purnima Spiegelman, +7 authors G. Everson
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2003
TLDR
Recurrence of primary sclerosing cholangitis was most often seen in patients who received maintenance corticosteroids, and the time to recurrence was not significantly different between those who were treated with maintenance, those who had complete records and survived more than 30 days after liver transplantation. Expand
Graft Failure From Severe Recurrent Primary Sclerosing Cholangitis Following Orthotopic Liver Transplantation
TLDR
This case illustrates that early, severe recurrence of PSC may occur, leading to graft failure and need for re-transplantation. Expand
Biliary strictures and recurrence after liver transplantation for primary sclerosing cholangitis: A retrospective multicenter analysis
  • T. Hildebrand, N. Pannicke, +19 authors T. Weismüller
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2016
TLDR
Donor age, IBD, and INR at LT are independent risk factors for BS and recPSC and allow for risk estimation depending on the recipient‐donor constellation. Expand
Recurrence of primary sclerosing cholangitis: What do we learn from several transplant centers?
  • P. Charatcharoenwitthaya, K. Lindor
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2008
TLDR
Three remarkably similar studies from the American and British communities in this issue of Liver Transplantation provide further evidence of the cumulative effect of recurrent PSC on survival outcome and reveal some potential risk factors, which might provide insight into the pathogenesis of the primary and recurrent disease. Expand
Liver transplantation for primary sclerosing cholangitis: timing, outcome, impact of inflammatory bowel disease and recurrence of disease.
  • R. Wiesner
  • Medicine
  • Best practice & research. Clinical gastroenterology
  • 2001
TLDR
There is an increased incidence of both acute and chronic rejection, hepatic artery thrombosis and biliary stricturing in PSC patients undergoing liver transplantation. Expand
Risk factors for recurrence of primary sclerosing cholangitis after liver transplantation
  • E. Cholongitas, V. Shusang, +7 authors A. Burroughs
  • Medicine
  • Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
  • 2008
TLDR
The presence of UC post‐ LT, and the need for maintenance steroids post‐LT, which is an independent factor, are associated with rPSC, and these findings could help elucidate a possible mechanism of PSC pathogenesis. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 27 REFERENCES
Cholangiographic features of biliary strictures after liver transplantation for primary sclerosing cholangitis: evidence of recurrent disease.
TLDR
Mural irregularity and diverticulum-like outpouchings and an overall appearance resembling PSC occur more frequently in PSC transplants than in transplants for other diseases, consistent with the hypothesis that PSC may recur in liver transplants. Expand
Orthotopic liver transplantation for primary sclerosing cholangitis. A 12-year single center experience.
TLDR
Liver transplantation provides excellent patient and graft survival rates for patients affected with PSC independent of pretransplant biliary tract surgery, however, known CCA or common duct frozen section biopsy specimen or both showing CCA are associated with poor recipient survival, and OLT should be proscribed in these cases. Expand
Biliary complications after liver transplantation in patients with preexisting sclerosing cholangitis.
TLDR
Biliary complications, particularly strictures at the choledochojejunostomy and debris in the intrahepatic and common ducts, were seen in six of ten liver transplant patients with preexisting sclerosing cholangitis; this is six times the frequency of biliary complications seen in other adult recipients. Expand
Fibrous and obliterative cholangitis in liver allografts: Evidence of recurrent primary sclerosing cholangitis?
TLDR
Although some of these lesions could represent a secondary sclerosing cholangitis, the observations suggest that primary scleroses cholangsitis may recur in the liver allograft. Expand
Liver transplantation for sclerosing cholangitis
TLDR
The clinical course of 37 patients who underwent 46 liver transplantations for primary and secondary sclerosing cholangitis was reviewed, demonstrating that excellent survival results can be achieved in this group of patients. Expand
Biliary strictures in hepatic transplants: prevalence and types in patients with primary sclerosing cholangitis vs those with other liver diseases.
TLDR
Intrahepatic and nonanastomotic extrahePatic biliary strictures are significantly more common in patients who have liver transplantation for primary sclerosing cholangitis than in Patients who receive allografts for other end-stage liver diseases. Expand
The first 100 liver transplantations at the Mayo Clinic.
TLDR
Of the first 100 liver transplantations at the Mayo Clinic, one- and 2-year patient survival was 83% and 70%, respectively, and although problems still remain, liver transplantation is a reasonable option for patients with end-stage liver disease. Expand
Diagnostic features and clinical outcome of ischemic‐type biliary complications after liver transplantation
TLDR
Early appearance of ischemic‐type biliary stricture features is associated with poor graft prognosis and is associatedwith increased morbidity, extended hospitalization and a higher incidence of repeat transplantation after orthotopic liver transplantation. Expand
Primary sclerosing cholangitis: a review of its clinical features, cholangiography, and hepatic histology.
TLDR
Reduced numbers of bile ducts, ductular proliferation, portal inflammation, and substantial copper deposition, in combination with piecemeal necrosis, are commonly seen in primary sclerosing cholangitis and indicate the need for cholANGiography. Expand
Ischemic‐type biliary complications after orthotopic liver transplantation
TLDR
It is demonstrated that the development of biliary strictures is strongly associated with the duration of cold ischemic storage of allografts in both Euro‐Collins solution and University of Wisconsin solution and that the occurrence of nonanastomotic biliaryrictures appears to be the result of the ischemia/reperfusion–induced tissue injuryassociated with the harvest and implantation of allogsrafts. Expand
...
1
2
3
...