Recurrence of blackwater fever: triggering of relapses by different antimalarials.

  title={Recurrence of blackwater fever: triggering of relapses by different antimalarials.},
  author={Jef van den Ende and Guy Coppens and T Verstraeten and T Van Haegenborgh and Katrien Depraetere and Alfons M Van Gompel and Erwin van den Enden and Jan Clerinx and Robert Colebunders and Willy E. Peetermans and Wilfried Schroyens},
  journal={Tropical medicine & international health : TM & IH},
  volume={3 8},
Five cases of blackwater fever (BWF) are described, all of whom had a history of recent quinine therapy. In two cases a second haemolytic crisis was induced by halofantrine, in one case also a third. Increasing frequency of this syndrome with its dramatic clinical presentation is to be expected as imported P. falciparum infection, parasite resistance to chloroquine and the use of quinine and other related antimalarials become more frequent. 


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