Rectal aspirin--absorption and antipyretic effect.

  title={Rectal aspirin--absorption and antipyretic effect.},
  author={K. Connolly and L. Lam and O. C. Ward},
  journal={Archives of Disease in Childhood},
  pages={713 - 715}
Rectal acetylsalicylic acid was given to 14 children who had undergone open heart surgery. The effect on their temperatures was similar whether 15--30 or 30--50 mg/kg was given. Either dose was more effective than no treatment. The greatest fall in temperature occurred after 4 or 5 hours. Rectal aspirin in a triglyceride base is effective in lowering postoperative temperature. It should also be of use in treating other fevers. A dose of 20--25 mg/kg is suggested. 
Correlation between dosage and antipyretic effect of aspirin in children
In all dosage regimens the average temperature was significantly reduced in the time interval 1–6 h after drug administration; the antipyretic effect, however, was significantly greater with the 10 and 15 mg/kg doses. Expand
Bioavariability of Rectal Aspirin in Neurosurgical Patients
Serum salicylate levels were determined fluorometrically in 12 neurosurgical patients after rectal and oral administration of 1.0 g aspirin, finding that rectal aspirin is useful in clinical situations in which medication is difficult by the oral route. Expand
A comparison of salicylic acid levels in normal subjects after rectal versus oral dosing.
The results suggested the rectal administration of a 600-mg suppository provides sufficient levels of salicylic acid within 90 minutes to meet or exceed that of oral aspirin. Expand
Gastro-duodenal injury associated with intake of 100-325 mg aspirin daily.
Results support findings by other groups, showing that doses of aspirin as low as 75 mg daily should be used in the management of elderly patients with thrombo-embolic disease. Expand
Evaluation of Novel Aspirin Suppository Formulation in HT-29 Human Adenocarcinoma Cells
As the baby-boomer population reaches an older age, there is an expected continual increase in hospitalization and the number of patients who are unable to take medications orally (NPOnothing throughExpand
Changes in body temperature after administration of antipyretics, LSD, Δ9-THC and related agents: II
  • W. G. Clark
  • Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1987
This compilation primarily covers the considerable amount of data published from 1981 through 1985 on the interactions of these drugs and thermoregulation, but data from many earlier papers not included in a previous compilation are also tabulated. Expand
Paracetamol suppositories: a comparative study.
There was a significant correlation between peak plasma concentrations and maximum drop in temperature and a lipophilic base produced better results than a hydrophilic base. Expand
Subsequent Management of Children with Febrile Convulsions
Dyslexia in children and young adults: three independent neuropsychological syndromes. Expand


The acute rectal toxicity of acetylsalicylic acid.
The LD50 ± S.E. of acetylsalicylic acid administered rectally to male albino rats was found to be significantly less than the oral LD50, which resulted in the most significant toxic signs being ataxia, drowsiness, dyspnea, pallor, diarrhea, and anorexia. Expand
Salicylate absorption from rectal suppositories.
  • E. L. Parrott
  • Chemistry, Medicine
  • Journal of pharmaceutical sciences
  • 1971
It was found that the rectal dose of aspirin and sodium salicylate was equivalent to the oral dose, and the release from theobroma oil suppositories containing cholesterol and glyceryl monostearate were inconclusive. Expand
Bioavailability of aspirin from commercial suppositories.
A comparison of the bioavailability of salicylate from five brands of commercially available aspirin rectal suppositories in an adult panel is presented. All brands show slow absorption compared toExpand
Study of antipyretic therapy in current use
  • J. Hunter
  • Medicine
  • Archives of disease in childhood
  • 1973
Several commonly used antipyretic therapies were compared in a series of 67 children. All regimens were more effective than exposure alone. Paracetamol and aspirin were comparable in antipyreticExpand
Drug absorption from the rectum. 3. Asprin and some aspirin derivatives.
The rectal absorption of aspirin, aluminum aspirin, and calcium carbaspirin was studied in dogs and no conclusions can be reached concerning any differences in absorption in the various bases or the commercial aspitin product. Expand
Value of monitoring plasma salicylate levels in treating juvenile rheumatoid arthritis. Observations in 42 cases.
The relation between salicylate dosage and plasma half-life accounts for the fact that small changes in dosage can result in large changes in plasma concentration. Expand
Value of monitoring plasma salicylate levels in Rectal aspirin-absorption and antipyretic effect 715 treating juvenile rheumatoid arthritis
  • Archives of Disease in Childhood
  • 1978
Bioavailability and tolerance studies on acetylsalicylic acid suppositories.
Rectal absorption from aspirin suppositories in children and adults.
Drug absorption from the rectum. III. Aspirin and some derivatives
  • Journal of Pharmaceutical Sciences,
  • 1970