Rectal and oral absorption of methylprednisolone acetate

@article{Garg1979RectalAO,
  title={Rectal and oral absorption of methylprednisolone acetate},
  author={D. Garg and J. Wagner and E. Sakmar and D. Weidler and K. Albert},
  journal={Clinical Pharmacology \& Therapeutics},
  year={1979},
  volume={26}
}
Rectal absorption of methylprednisolone acetate and oral absorption of methylprednisolone and methylprednisolone acetate were investigated in a single‐dose 3‐way crossover study of 12 normal male volunteers. The median value of bioavailability (relative to oral dose) of methylprednisolone acetate based on unchanged methylprednisolone plasma levels was 14.2% after rectal administration, suggesting that the drug exerts its therapeutic effect topically rather than systemically. In contrast, the… Expand
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