Rectal absorption of lamotrigine compressed tablets.

  title={Rectal absorption of lamotrigine compressed tablets.},
  author={Angela K. Birnbaum and Robert L Kriel and R Todd Burkhardt and Rory P. Remmel},
  volume={41 7},
PURPOSE Interruption of oral drug administration poses a significant clinical problem for antiepileptic drugs that have no parenteral formulation. If a drug is absorbed rectally, rectal administration can be a useful alternative when the oral route of administration is not possible. The purpose of this study was to compare the single-dose pharmacokinetics of lamotrigine (LTG) compressed tablets after rectal and oral administration in healthy volunteers. METHODS A single LTG compressed tablet… CONTINUE READING