• Corpus ID: 212537828

Rectal Hyoscine-N-Butylbromide Safely Accelerates Progress of Labor in Primipara: A Placebo- Controlled Study

@inproceedings{Shedid2012RectalHS,
  title={Rectal Hyoscine-N-Butylbromide Safely Accelerates Progress of Labor in Primipara: A Placebo- Controlled Study},
  author={Ayman A. Shedid},
  year={2012}
}

• A. Shedid
• Published 2012
• Medicine

Objectives: To evaluate the applicability of the administration of Hyoscine-N-butylbromide (HBB) as a therapeutic modality for acceleration of progress of labor in primipara. Patients & Methods: The study included 150 primiparae having normal-sized singleton fetus with cephalic presentation. At time of pregnancy diagnosis, patients' demographic and body constitutional data were determined. Parturient were randomly allocated into two equal groups: Control group received paracetamol 800 mg rectal suppository as placebo and Study group received buscopan compositum adult supp containing HBB 10 mg and paracetamol 800 mg. Both groups received nalbuphine, 10 mg intramuscular injection. All medications were administered during the active phase of the first stage of labor when cervical dilatation was 4 cm with 80% cervical effacement and regular uterine contraction at frequency of 3-4 contractions every 10 minutes. The durations of the first and second stages of labor were determined. Results: Mean duration of both first and second stages and total durations of active labor were significantly shorter in study group compared to control group. Fifty parturient had spontaneous rupture of membranes and 33 parturient required oxytocin augmentation with significantly higher frequency of spontaneous membrane rupture and the need for oxytocin in control group compared to study group. As regards mode of delivery, 40 parturient required instrumental aid with significantly higher frequency of need for instrumental delivery in control group compared to study group. Twenty-two neonates had Apgar score of <9; 13 in control and 9 in study group with non-significant difference between both groups. Conclusion: Rectal administration of HBB for primipara allows significant reduction of duration of first and second stages of labor without inducing significant maternal or fetal complications. Meticulous observation of the progress of pregnancy spared the possibilities for hastened delivery with its subsequent complications, so it is mandatory for such cases. [Ayman Ahmed A. Shedid. Rectal Hyoscine-N-Butylbromide Safely Accelerates Progress of Labor in Primipara: A Placebo-Controlled Study. J Am Sci 2012;8(8):512-516]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 78