Rectal Drug Administration

@article{Boer1982RectalDA,
  title={Rectal Drug Administration},
  author={Albertus G. de Boer and Frits Moolenaar and L. G. J. Leede and D. D. Breimer},
  journal={Clinical Pharmacokinetics},
  year={1982},
  volume={7},
  pages={285-311}
}
SummaryThe human rectum represents a body cavity in which drugs can be easily introduced and retained and from which absorption is well possible. There are important therapeutic reasons why it is sometimes preferable to give a drug rectally rather than orally, e.g. in cases of nausea and vomiting. Drawbacks of rectal drug administration include the interruption of absorption by defaecation and lack of patient acceptability. The mechanism of drug absorption from the rectum is probably no… 
Rate controlled rectal drug delivery in man
Abstract The human rectum represents a body cavity in which certain drug formulations can be easily introduced and retained and from which absorption is well possible. There are important practical
Rectal absorption enhancement of peptide drugs
Abstract There are various reasons for rectal drug administration. Two of the most obvious ones are situations when patients are vomiting or suffering from nausea, while it has also been shown that
Drug absorption by sublingual and rectal routes.
TLDR
The disadvantages associated with administration of drugs rectally include: interruption of absorption by defaccation, which may occur particularly with irritant drugs; the surface area of the rectum is far smaller for absorption than that of the duodenum, and this may produce problems with dissolution of some drugs.
Rectal versus oral absorption of diflunisal in man
Abstract Rectal absorption of diflunisal from various dosage forms was studied in man. The rectal dosage forms included fatty and macrogol suppositories, an aqueous suspension and solutions with
Physiological and Pharmaceutical Considerations for Rectal Drug Formulations
  • S. Hua
  • Medicine
    Front. Pharmacol.
  • 2019
TLDR
This review will address the physiological and pharmaceutical considerations influencing rectal drug delivery as well as the conventional and novel drug delivery approaches.
The suppository form of antibiotic administration: pharmacokinetics and clinical application.
The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can
Pharmacokinetics of Rectal Drug Administration, Part II
TLDR
In Part II of this article, this discussion is extended to drugs which act peripherally and to methods of enhancing rectal drug absorption.
Relative Bioavailability of Rectally Administered Phenobarbital Sodium Parenteral Solution
TLDR
The parenteral phenobarbital sodium solution given rectally is well absorbed and provides a useful alternative route of administration in comparison with the same preparation given intramuscularly.
Evaluation of the Colonic Drug Absorption in Patients with an Artificial Intestinal Stoma and by Colonoscopy in Normal Volunteers
TLDR
Plasma concentration/ time profiles of both drugs after oral and colonic dosing followed similar time courses, and mean peak concentrations were lower after colonic compared with oral dosing.
Review of the rectal use of opioids.
TLDR
The physiology of rectal drug absorption and such data as exists on the different opioids that have been administered by this route are reviewed.
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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Biopharmaceutics of rectal administration of drugs in man. Part 5. : Absorption rate and bioavailability of glafenine after oral and rectal administration
TLDR
It is shown that rectal administration of glafenine and its salt can not be considered as a rotional therapy and the decline in plasma concentrations was observed to be multiphasic.
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