Rectal Drug Administration

@article{Boer1982RectalDA,
  title={Rectal Drug Administration},
  author={Albertus G. de Boer and Frits Moolenaar and L. G. J. Leede and D. D. Breimer},
  journal={Clinical Pharmacokinetics},
  year={1982},
  volume={7},
  pages={285-311}
}
SummaryThe human rectum represents a body cavity in which drugs can be easily introduced and retained and from which absorption is well possible. There are important therapeutic reasons why it is sometimes preferable to give a drug rectally rather than orally, e.g. in cases of nausea and vomiting. Drawbacks of rectal drug administration include the interruption of absorption by defaecation and lack of patient acceptability. The mechanism of drug absorption from the rectum is probably no… 

Drug absorption by sublingual and rectal routes.

The disadvantages associated with administration of drugs rectally include: interruption of absorption by defaccation, which may occur particularly with irritant drugs; the surface area of the rectum is far smaller for absorption than that of the duodenum, and this may produce problems with dissolution of some drugs.

Physiological and Pharmaceutical Considerations for Rectal Drug Formulations

  • S. Hua
  • Biology, Medicine
    Front. Pharmacol.
  • 2019
This review will address the physiological and pharmaceutical considerations influencing rectal drug delivery as well as the conventional and novel drug delivery approaches.

The suppository form of antibiotic administration: pharmacokinetics and clinical application.

The rectal route of antibiotic administration might be used effectively when other routes of administration are inadequate or unsuitable. With the use of various adjuvants, the rectal route can

Pharmacokinetics of Rectal Drug Administration, Part II

In Part II of this article, this discussion is extended to drugs which act peripherally and to methods of enhancing rectal drug absorption.

Relative Bioavailability of Rectally Administered Phenobarbital Sodium Parenteral Solution

The parenteral phenobarbital sodium solution given rectally is well absorbed and provides a useful alternative route of administration in comparison with the same preparation given intramuscularly.

Evaluation of the Colonic Drug Absorption in Patients with an Artificial Intestinal Stoma and by Colonoscopy in Normal Volunteers

Plasma concentration/ time profiles of both drugs after oral and colonic dosing followed similar time courses, and mean peak concentrations were lower after colonic compared with oral dosing.

Review of the rectal use of opioids.

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First order analysis of the results indicated that the drugs are best absorbed from true solutions in water, or from water suspensions of the drug.
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