Recruitment to multicentre trials—lessons from UKCTOCS: descriptive study

  title={Recruitment to multicentre trials—lessons from UKCTOCS: descriptive study},
  author={Usha Menon and Aleksandra Gentry-Maharaj and Andy Ryan and Aarti Sharma and Matthew G Burnell and Rachel Hallett and Sara J Lewis and Alberto L{\'o}pez and Keith Godfrey and David H Oram and Jonathan J O Herod and Karin Williamson and Mourad M W Seif and Ian V. Scott and Tim A Mould and Robert P Woolas and John B. Murdoch and Stephen Dobbs and Nazar N. Amso and Simon C Leeson and Derek Cruickshank and Ali McGuire and Stuart Campbell and Lesley Fallowfield and Steve J Skates and Mahesh K. B. Parmar and Ian J. Jacobs},
  journal={BMJ : British Medical Journal},
OBJECTIVE To describe the factors that contributed to successful recruitment of more than 200,000 women to the UK Collaborative Trial of Ovarian Cancer Screening, one of the largest ever randomised controlled trials. DESIGN Descriptive study. SETTING 13 NHS trusts in England, Wales, and Northern Ireland. PARTICIPANTS Postmenopausal women aged 50-74; exclusion criteria included ovarian malignancy, bilateral oophorectomy, increased risk of familial ovarian cancer, active non-ovarian… CONTINUE READING