Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers.

@article{Weitzman1996RecruitmentOW,
  title={Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers.},
  author={Matthew D Weitzman and Krishna J. Fisher and James Michael Wilson},
  journal={Journal of virology},
  year={1996},
  volume={70 3},
  pages={1845-54}
}
Replication of a human parvovirus, adeno-associated virus (AAV), is facilitated by coinfection with adeno-virus to provide essential helper functions. We have used the techniques of in situ hybridization and immunocytochemistry to characterize the localization of AAV replication within infected cells, Previous studies have shown that adenovirus establishes foci called replication centers within the nucleus, where adenoviral replication and transcription occur. Our studies indicate that AAV is… CONTINUE READING

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