Recruitment of the proneural gene scute to the Drosophila sex-determination pathway.

@article{Wrischnik2003RecruitmentOT,
  title={Recruitment of the proneural gene scute to the Drosophila sex-determination pathway.},
  author={Lisa A Wrischnik and John R. Timmer and Lisa A Megna and Thomas W. Cline},
  journal={Genetics},
  year={2003},
  volume={165 4},
  pages={2007-27}
}
In flies, scute (sc) works with its paralogs in the achaete-scute-complex (ASC) to direct neuronal development. However, in the family Drosophilidae, sc also acquired a role in the primary event of sex determination, X chromosome counting, by becoming an X chromosome signal element (XSE)-an evolutionary step shown here to have occurred after sc diverged from its closest paralog, achaete (ac). Two temperature-sensitive alleles, sc(sisB2) and sc(sisB3), which disrupt only sex determination, were… CONTINUE READING

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