Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.

@article{Shamay2006RecruitmentOT,
  title={Recruitment of the de novo DNA methyltransferase Dnmt3a by Kaposi's sarcoma-associated herpesvirus LANA.},
  author={Meir Shamay and Anita Krithivas and Jun Zhang and Stephen D. Hayward},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 39},
  pages={14554-9}
}
The Kaposi's sarcoma-associated herpesvirus LANA protein is expressed in all Kaposi's sarcoma-associated herpesvirus-infected cells, including the tumor cells of endemic and AIDS-associated Kaposi sarcoma, primary effusion lymphoma, and Castleman disease. LANA modulates cell gene expression, but the mechanisms of LANA-mediated transcriptional reprogramming are poorly understood. LANA-repressed cell genes were identified by using retroviral-transduced telomerase-immortalized microvascular… CONTINUE READING
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