Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function.

@article{Pang2005RecruitmentOP,
  title={Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function.},
  author={Jian-Hong Pang and Astrid Kraemer and Samantha J Stehbens and Margaret C Frame and Alpha S. Yap},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 4},
  pages={
          3043-50
        }
}
Classical cadherin adhesion molecules can function as adhesion-activated cell-signaling receptors. One key target for cadherin signaling is the lipid kinase phosphoinositide (PI) 3-kinase, which is recruited to cell-cell contacts and activated by E-cadherin. In this study, we sought to identify upstream factors necessary for E-cadherin to activate PI 3-kinase signaling. We found that inhibition of tyrosine kinase signaling blocked recruitment of PI 3-kinase to E-cadherin contacts and abolished… CONTINUE READING

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