Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions.

@article{Klein2000RecruitmentON,
  title={Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands. Influence of DNA-heterodimer interactions.},
  author={Elliott S Klein and J W Wang and Berket Khalifa and S A Gavigan and Roshantha A. S. Chandraratna},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 25},
  pages={19401-8}
}
Ligand activation of retinoic acid receptors (RARs) involves coordinated changes in their interaction with coregulatory molecules. Binding of the agonist all-trans-retinoic acid to the RAR results in increased interaction with coactivator molecules as well as a decreased interaction with corepressor molecules. Thus, an all-trans-retinoic acid antagonist might function either by preventing agonist induction of such events or, additionally, by actively increasing repression via corepressor… CONTINUE READING
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