Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.

@article{GilBernab2012RecruitmentOM,
  title={Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice.},
  author={Ana M. Gil-Bernab{\'e} and Spela Ferjancic and Monika Tlalka and Lei Zhao and Philip D. Allen and Jae Hong Im and Karla Watson and Sally A. Hill and Ali Amirkhosravi and John L. Francis and Jeffrey W Pollard and Wolfram Ruf and Ruth J. Muschel},
  journal={Blood},
  year={2012},
  volume={119 13},
  pages={
          3164-75
        }
}
Tissue factor (TF) expression by tumor cells correlates with metastasis clinically and supports metastasis in experimental settings. However, the precise pathways coupling TF to malignancy remain incompletely defined. Here, we show that clot formation by TF indirectly enhances tumor cell survival after arrest in the lung, during experimental lung metastasis, by recruiting macrophages characterized by CD11b, CD68, F4/80, and CX(3)CR1 (but not CD11c) expression. Genetic or pharmacologic… CONTINUE READING
Tweets
This paper has been referenced on Twitter 1 time. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 102 CITATIONS, ESTIMATED 53% COVERAGE

202 Citations

0102030'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 202 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

Similar Papers

Loading similar papers…