Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p.

@article{Hershkovits2006RecruitmentOM,
  title={Recruitment of mRNA cleavage/polyadenylation machinery by the yeast chromatin protein Sin1p/Spt2p.},
  author={Gitit Hershkovits and Haim Bangio and Ronit Cohen and Don Jay Katcoff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 26},
  pages={9808-13}
}
The yeast chromatin protein Sin1p/Spt2p has long been studied, but the understanding of its function has remained elusive. The protein has sequence similarity to HMG1, specifically binds crossing DNA structures, and serves as a negative transcriptional regulator of a small family of genes that are activated by the SWI/SNF chromatin-remodeling complex. Recently, it has been implicated in maintaining the integrity of chromatin during transcription elongation. Here we present experiments whose… CONTINUE READING
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