Recruitment of insulin receptor substrate-1 and activation of NF-κB essential for midkine growth signaling through anaplastic lymphoma kinase

@article{Kuo2007RecruitmentOI,
  title={Recruitment of insulin receptor substrate-1 and activation of NF-κB essential for midkine growth signaling through anaplastic lymphoma kinase},
  author={Angera H. Kuo and Gerald E. Stoica and Anna Tate Riegel and Anton Wellstein},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={859-869}
}
Anaplastic lymphoma kinase (ALK) is a transmembrane receptor tyrosine kinase in the insulin receptor superfamily. We recently demonstrated that the growth factors pleiotrophin (PTN) and midkine (MK) are ligands for ALK and that upon ALK activation, insulin receptor substrate-1 (IRS-1) and other substrates are phosphorylated. Here, the role of IRS-1 in… CONTINUE READING