Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.

@article{Shen2009RecruitmentOF,
  title={Recruitment of fanconi anemia and breast cancer proteins to DNA damage sites is differentially governed by replication.},
  author={Xi Hong Shen and Huong Thu Do and Yongjiang Li and Woo-Hyun Chung and Maria Tomasz and Johan P. de Winter and Bing Xia and Stephen J Elledge and Weidong Wang and Lei Li},
  journal={Molecular cell},
  year={2009},
  volume={35 5},
  pages={716-23}
}
Fanconi anemia (FA) is characterized by cellular hypersensitivity to DNA crosslinking agents, but how the Fanconi pathway protects cells from DNA crosslinks and whether FA proteins act directly on crosslinks remain unclear. We developed a chromatin-IP-based strategy termed eChIP and detected association of multiple FA proteins with DNA crosslinks in vivo. Interdependence analyses revealed that crosslink-specific enrichment of various FA proteins is controlled by distinct mechanisms. BRCA… CONTINUE READING
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