Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription.

Abstract

Runx2, best known for its role in regulating osteoblast-specific gene expression, also plays an increasingly recognized role in prostate and breast cancer metastasis. Using the C4-2B/Rx2(dox) prostate cancer cell line that conditionally expressed Runx2 in response to doxycycline treatment, we identified and characterized G9a, a histone methyltransferase, as… (More)
DOI: 10.1002/jcb.24114

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@article{Purcell2012RecruitmentOC, title={Recruitment of coregulator G9a by Runx2 for selective enhancement or suppression of transcription.}, author={Daniel J Purcell and Omar Khalid and Chen-Yin Ou and Gillian H. Little and Baruch Frenkel and Sanjeev Kumar Baniwal and Michael R Stallcup}, journal={Journal of cellular biochemistry}, year={2012}, volume={113 7}, pages={2406-14} }