Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription.

@article{Govindan2010RecruitmentOC,
  title={Recruitment of cAMP-response element-binding protein and histone deacetylase has opposite effects on glucocorticoid receptor gene transcription.},
  author={Manjapra Variath Govindan},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 7},
  pages={4489-510}
}
Glucocorticoids control the synthesis of the glucocorticoid receptor (GR) in various tissues through a negative feedback regulation of the mRNA. In this study, we have identified feedback regulatory domains in the human GR gene promoter and examined the roles of GR, the cAMP-response element-binding protein (CREB), and HDAC-6 in association with promoter elements of the human GR gene. Using breast cancer T47D and HeLa-GR cells, we identify specific negative glucocorticoid-response elements in… CONTINUE READING
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CREB and HDAC Have Opposite Effects on GR Gene Transcription 4510 JOURNAL OF BIOLOGICAL CHEMISTRY

  • M. G. Guenther, M. A. Lazar
  • Methods Enzymol. 364,
  • 2003
1 Excerpt

NUMBER 7 JOURNAL OF BIOLOGICAL CHEMISTRY 4509 at U iv of St A nrew s on A ril 26

  • S. J. Levine, T. Benfield, J. H. Shelhamer
  • Am. J. Respir. Cell CREB and HDAC Have Opposite…
  • 1996
1 Excerpt

CRCCrit

  • A. P. Wolffe, D. Pruss
  • Rev . Biochem .
  • 1986

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