Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.

@article{Shechter2013RecruitmentOB,
  title={Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus.},
  author={Ravid Shechter and Omer Miller and Gili Yovel and Neta Rosenzweig and Anat London and Julia M. Ruckh and Ki-Wook Kim and C. G. A. Harrison and Vyacheslav Kalchenko and Peter Bendel and Sergio A Lira and Steffen Jung and Michal Schwartz},
  journal={Immunity},
  year={2013},
  volume={38 3},
  pages={
          555-69
        }
}
Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood. Here, we show that although of common origin, the homing of proinflammatory (M1) and the "alternatively activated" anti-inflammatory (M2) macrophages to traumatized spinal cord (SC) was distinctly regulated, neither being through breached blood-brain barrier. The M1 macrophages (Ly6c(hi)CX3CR1(lo)) derived from monocytes homed in a CCL2 chemokine-dependent manner… CONTINUE READING
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