Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation.

@article{Felinski2001RecruitmentOA,
  title={Recruitment of an RNA polymerase II complex is mediated by the constitutive activation domain in CREB, independently of CREB phosphorylation.},
  author={Edward A Felinski and Jiyoung Kim and Junfeng Lu and Patrick G. Quinn},
  journal={Molecular and cellular biology},
  year={2001},
  volume={21 4},
  pages={1001-10}
}
The cAMP response element binding protein (CREB) is a bifunctional transcription activator, exerting its effects through a constitutive activation domain (CAD) and a distinct kinase inducible domain (KID), which requires phosphorylation of Ser-133 for activity. Both CAD and phospho-KID have been proposed to recruit polymerase complexes, but this has not been directly tested. Here, we show that the entire CREB activation domain or the CAD enhanced recruitment of a complex containing TFIID, TFIIB… CONTINUE READING

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