Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts.

  title={Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts.},
  author={Ziye Sui and Attila D Kovacs and Sanjay B. Maggirwar},
  journal={Biochemical and biophysical research communications},
  volume={345 4},
Glycogen synthase kinase (GSK)-3beta has emerged as a key molecule that regulates neuronal apoptosis. To examine the molecular mechanism(s) through which GSK-3beta regulates this process, we studied the subcellular localization of GSK-3beta following exposure of the cells to well-characterized apoptotic stimuli. Here, we report that the induction of apoptosis by withdrawal of serum and potassium triggers dephosphorylation of GSK-3beta at serine 9 and subsequent translocation of these molecules… CONTINUE READING


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