Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα

@inproceedings{Tan1999RecruitmentOA,
  title={Recruitment of a ROC1–CUL1 Ubiquitin Ligase by Skp1 and HOS to Catalyze the Ubiquitination of IκBα},
  author={P. C. andZarepour Tan and Serge Yu. Fuchs and Angus Chen and Kenneth Wu and Carlos William Gomez and Ze'ev A Ronai and Zhen-qiang Pan},
  year={1999}
}
Abstract Activation of the transcription factor NF-κB in response to proinflammatory stimuli requires the phosphorylation-triggered and ubiquitin-dependent degradation of the NF-κB inhibitor, IκBα. Here, we show the in vitro reconstitution of the phosphorylation-dependent ubiquitination of IκBα with purified components. ROC1, a novel SCF-associated protein, is recruited by cullin 1 to form a quaternary SCF HOS –ROC1 holoenzyme (with Skp1 and the β-TRCP homolog HOS). SCF HOS –ROC1 binds IKK… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 45 CITATIONS

The role of von Hippel-Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma.

  • American journal of physiology. Renal physiology
  • 2004
VIEW 8 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins.

  • Molecular biology of the cell
  • 2001
VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Ubiquitin-mediated proteolysis: biological regulation via destruction.

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2000
VIEW 3 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…