Recruitment of TRF2 to laser-induced DNA damage sites.

  title={Recruitment of TRF2 to laser-induced DNA damage sites.},
  author={Nazmul Huda and Satoshi Abe and Ling Gu and Marc S. Mendonca and Samarendra Kumar Mohanty and David R Gilley},
  journal={Free radical biology & medicine},
  volume={53 5},
Several lines of evidence suggest that the telomere-associated protein TRF2 plays critical roles in the DNA damage response. TRF2 is rapidly and transiently phosphorylated by an ATM-dependent pathway in response to DNA damage and this DNA damage-induced phosphoryation is essential for the DNA-PK-dependent pathway of DNA double-strand break repair (DSB). However, the type of DNA damage that induces TRF2 localization to the damage sites, the requirement for DNA damage-induced phosphorylation of… CONTINUE READING