Recruitment of Eph receptors into signaling clusters does not require ephrin contact

@article{WimmerKleikamp2004RecruitmentOE,
  title={Recruitment of Eph receptors into signaling clusters does not require ephrin contact},
  author={Sabine H. Wimmer-Kleikamp and Peter W Janes and Anthony Squire and Philippe I. H. Bastiaens and Martin Lackmann},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={164},
  pages={661 - 666}
}
Eph receptors and their cell membrane-bound ephrin ligands regulate cell positioning and thereby establish or stabilize patterns of cellular organization. Although it is recognized that ephrin clustering is essential for Eph function, mechanisms that relay information of ephrin density into cell biological responses are poorly understood. We demonstrate by confocal time-lapse and fluorescence resonance energy transfer microscopy that within minutes of binding ephrin-A5-coated beads, EphA3… CONTINUE READING
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