Recruitment of Eph receptors into signaling clusters does not require ephrin contact

  title={Recruitment of Eph receptors into signaling clusters does not require ephrin contact},
  author={Sabine H. Wimmer-Kleikamp and Peter W Janes and Anthony Squire and Philippe I. H. Bastiaens and Martin Lackmann},
  journal={The Journal of Cell Biology},
  pages={661 - 666}
Eph receptors and their cell membrane-bound ephrin ligands regulate cell positioning and thereby establish or stabilize patterns of cellular organization. Although it is recognized that ephrin clustering is essential for Eph function, mechanisms that relay information of ephrin density into cell biological responses are poorly understood. We demonstrate by confocal time-lapse and fluorescence resonance energy transfer microscopy that within minutes of binding ephrin-A5-coated beads, EphA3… CONTINUE READING
Highly Cited
This paper has 115 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 60 extracted citations

PTP1B regulates Eph receptor function and trafficking

The Journal of cell biology • 2010
View 5 Excerpts
Method Support
Highly Influenced

116 Citations

Citations per Year
Semantic Scholar estimates that this publication has 116 citations based on the available data.

See our FAQ for additional information.


Publications referenced by this paper.
Showing 1-10 of 25 references

Eph signaling: a structural view

Trends in Neurosciences • 2003
View 1 Excerpt

Crystal structure of an Eph receptor - ephrin complex

K. R. Rajashankar, M. Lackmann, C. A. Cowan, M. Henkemeyer, D. B. Nikolov