Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.

@article{Savla2008RecruitmentOD,
  title={Recruitment of Drosophila Polycomb-group proteins by Polycomblike, a component of a novel protein complex in larvae.},
  author={Urmi Savla and Judith J Benes and Junyu Zhang and Richard S. Jones},
  journal={Development},
  year={2008},
  volume={135 5},
  pages={813-7}
}
Polycomb-group (PcG) proteins are highly conserved epigenetic transcriptional repressors that play central roles in numerous examples of developmental gene regulation. Four PcG repressor complexes have been purified from Drosophila embryos: PRC1, PRC2, Pcl-PRC2 and PhoRC. Previous studies described a hierarchical recruitment pathway of PcG proteins at the bxd Polycomb Response Element (PRE) of the Ultrabithorax (Ubx) gene in larval wing imaginal discs. The DNA-binding proteins Pho and/or Phol… CONTINUE READING