Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.

@article{Wang2013RecruitmentOB,
  title={Recruitment of Brd4 to the human papillomavirus type 16 DNA replication complex is essential for replication of viral DNA.},
  author={Xin Wang and Christine M. Helfer and Neha J. Pancholi and James E. Bradner and Jianxin You},
  journal={Journal of virology},
  year={2013},
  volume={87 7},
  pages={3871-84}
}
Replication of the human papillomavirus (HPV) DNA genome relies on viral factors E1 and E2 and the cellular replication machinery. Bromodomain-containing protein 4 (Brd4) interacts with viral E2 protein to mediate papillomavirus (PV) genome maintenance and viral transcription. However, the functional role of Brd4 in the HPV life cycle remains to be clearly defined. In this study, we provide the first look into the E2-Brd4 interaction in the presence of other important viral factors, such as the… CONTINUE READING

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