Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex

@article{Adams2006RecruitmentOA,
  title={Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex},
  author={Kate E. Adams and Annette L Medhurst and D Alwyn Dart and Nicholas D Lakin},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3894-3904}
}
ATM and ATR are two related kinases essential for signalling DNA damage. Although ATM is thought to be the principle kinase responsible for signalling ionising radiation (IR)-induced DNA damage, ATR also contributes to signalling this form of genotoxic stress. However, the molecular basis of differential ATM and ATR activation in response to IR remains unclear. Here, we report that ATR is recruited to sites of IR-induced DNA damage significantly later than activation of ATM. We show that ATR is… CONTINUE READING
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