Recruitment failure and futility were the most common reasons for discontinuation of clinical drug trials. Results of a nationwide inception cohort study in the Netherlands.

Abstract

OBJECTIVES The objective of the study was to identify the reasons for discontinuation of clinical drug trials and to evaluate whether efficacy-related discontinuations were adequately planned in the trial protocol. STUDY DESIGN AND SETTING All clinical drug trials in the Netherlands, reviewed by institutional review boards in 2007, were followed until… (More)
DOI: 10.1016/j.jclinepi.2017.05.001

Topics

Cite this paper

@article{Bogert2017RecruitmentFA, title={Recruitment failure and futility were the most common reasons for discontinuation of clinical drug trials. Results of a nationwide inception cohort study in the Netherlands.}, author={Cornelis A van den Bogert and Patrick C. Souverein and Cecile T. M. Brekelmans and Susan W. J. Janssen and Gerard H. Ko{\"{e}ter and Hubert G. M. Leufkens and L. M. Bouter}, journal={Journal of clinical epidemiology}, year={2017}, volume={88}, pages={140-147} }