Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair

@inproceedings{Douwel2017RecruitmentAP,
  title={Recruitment and positioning determine the specific role of the XPF‐ERCC1 endonuclease in interstrand crosslink repair},
  author={Daisy Klein Douwel and Wouter S Hoogenboom and Rick A. C. M. Boonen and Puck Knipscheer},
  booktitle={The EMBO journal},
  year={2017}
}
XPF-ERCC1 is a structure-specific endonuclease pivotal for several DNA repair pathways and, when mutated, can cause multiple diseases. Although the disease-specific mutations are thought to affect different DNA repair pathways, the molecular basis for this is unknown. Here we examine the function of XPF-ERCC1 in DNA interstrand crosslink (ICL) repair. We used Xenopus egg extracts to measure both ICL and nucleotide excision repair, and we identified mutations that are specifically defective in… CONTINUE READING
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