Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif.

@article{Tridandapani1997RecruitmentAP,
  title={Recruitment and phosphorylation of SH2-containing inositol phosphatase and Shc to the B-cell Fc gamma immunoreceptor tyrosine-based inhibition motif peptide motif.},
  author={Susheela Tridandapani and Todd W Kelley and Madhura Pradhan and D. Paul Cooney and Louis B. Justement and K Mark Coggeshall},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 8},
  pages={4305-11}
}
Recently, we and others have demonstrated that negative signaling in B cells selectively induces the tyrosine phosphorylation of a novel inositol polyphosphate phosphatase, p145SHIP. In this study, we present data indicating that p145SHIP binds directly a phosphorylated motif, immunoreceptor tyrosine-based inhibition motif (ITIM), present in the cytoplasmic domain of Fc gammaRIIB1. Using recombinant SH2 domains, we show that binding is mediated via the Src homology region 2 (SH2)-containing… CONTINUE READING