Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.

@article{Pryce2009RecruitmentAM,
  title={Recruitment and maintenance of tendon progenitors by TGFbeta signaling are essential for tendon formation.},
  author={Brian A Pryce and Spencer S. Watson and Nicholas D Murchison and Julia A. Staverosky and Nicole D{\"u}nker and Ronen Schweitzer},
  journal={Development},
  year={2009},
  volume={136 8},
  pages={1351-61}
}
Tendons and ligaments mediate the attachment of muscle to bone and of bone to bone to provide connectivity and structural integrity in the musculoskeletal system. We show that TGFbeta signaling plays a major role in the formation of these tissues. TGFbeta signaling is a potent inducer of the tendon progenitor (TNP) marker scleraxis both in organ culture and in cultured cells, and disruption of TGFbeta signaling in Tgfb2(-/-);Tgfb3(-/-) double mutant embryos or through inactivation of the type… CONTINUE READING
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