Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.

@article{Reiss2011RecruitmentAA,
  title={Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.},
  author={Simon Reiss and Ilka Rebhan and Perdita Backes and In{\'e}s Romero-Brey and Holger Erfle and Petr Matula and Lars Kaderali and Marion Poenisch and Hagen Blankenburg and Marie-Sophie Hiet and Thomas Longerich and Sarah Diehl and Fidel Ram{\'i}rez and Tamas Balla and Karl Rohr and Artur Kaul and Sandra B{\"u}hler and Rainer Pepperkok and Thomas Lengauer and Mario Albrecht and Roland Eils and Peter Schirmacher and Volker Lohmann and Ralf Bartenschlager},
  journal={Cell host & microbe},
  year={2011},
  volume={9 1},
  pages={32-45}
}
Hepatitis C virus (HCV) is a major causative agent of chronic liver disease in humans. To gain insight into host factor requirements for HCV replication, we performed a siRNA screen of the human kinome and identified 13 different kinases, including phosphatidylinositol-4 kinase III alpha (PI4KIIIα), as being required for HCV replication. Consistent with elevated levels of the PI4KIIIα product phosphatidylinositol-4-phosphate (PI4P) detected in HCV-infected cultured hepatocytes and liver tissue… CONTINUE READING
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